Mcaa: Development of Laboratory Skills in Molecular Biology to Examine Patterns of Calcitonin and Calcitonin Receptor Gene Expression in Cartilaginous Fishes
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Tissue Specific Expression of Human Calcitonin Gene in Potato Tubers by an Organ Specific Promoter
To increase the production level of heterologous proteins in plants, strategies such as choice of strongerpromoters, optimization of codon usage and specific localization of foreign proteins are of major concern.Calcitonin (CT), a 32 amino acid polypeptide is a powerful and specific inhibitor of bone resorption and isused to treat several human diseases. Calcitonin activity is...
متن کاملThe effect of 17β-estradiol on gene expression of calcitonin gene-related peptide and some pro-inflammatory mediators in peripheral blood mononuclear cells from patients with pure menstrual migraine
Objective(s):The neuropeptide calcitonin gene-related peptide (CGRP) has long been postulated to play an integral role in the pathophysiology of migraine. Earlier studies showed that CGRP can stimulate the synthesis and release of nitric oxide (NO) and cytokines from trigeminal ganglion glial cells. The purpose of this study was to determine the effect of 17β-estradiol in regulation of CGRP exp...
متن کاملIntrathecal Amylin and Salmon Calcitonin Affect Formalin Induced c-Fos Expression in the Spinal Cord of Rats
Background: Amylin and Salmon Calcitonin belong to the calcitonin family of peptides and have high affinity binding sites in the rat spinal cord. The aim of this study was to characterize receptors for Amylin and Salmon Calcitonin functionally in the spinal cord of rats. We assessed the expression of c-Fos in response to intraplantar formalin in the lumbar regions of the spinal cord in consciou...
متن کاملPreparation and biodistribution study of 67Ga-gallium calcitonin
Introduction: In order to develop a radiolabeled calcitonin (CT) derivative for receptor imaging studies, CT was successively labeled with 67Ga-gallium chloride. Methods: The best results of the conjugation were obtained by the addition of 0.5 ml of a CT nasal pharmaceutical solution (1100 IU) to a glass tube pre-coated with DTPA-dianhydride (0.01 mg) at 25°C with continuous mild st...
متن کاملThe effect of hypothyroidism on the trigeminal calcitonin gene-related peptide containing motoneurons: an immunohisto-chemical study in late neonatal life
CGRP, which coexists with acetylcholine in trigeminal motoneurons, could be one of the regulatory anterograde factors responsible for the enhanced expression of AChR subunits in neuromuscular junction. It has been also shown that low level of thyroid hormone plasma concentration has influence on the transitional development of muscle fibers and related motoneurons through a sever reduction in A...
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تاریخ انتشار 2009